DEEP MUTATIONAL SCANNING REVEALS TRANSMEMBRANE FEATURES GOVERNING SURFACE EXPRESSION OF THE B CELL ANTIGEN RECEPTOR

Deep mutational scanning reveals transmembrane features governing surface expression of the B cell antigen receptor

B cells surveil the body for foreign matter using their surface-expressed B cell antigen receptor (BCR), a tetrameric complex comprising a membrane-tethered antibody (mIg) that binds antigens and a signaling dimer (CD79AB) that conveys this interaction to the B cell.Recent cryogenic electron microscopy (cryo-EM) structures of IgM and IgG isotype BC

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